Phillies vs. Astros predictions, picks and best bets: Houston looking for the series sweep

Published On: June 30, 2025

On Thursday afternoon, the Philadelphia Phillies concluded their series against the Houston Astros. We have the finest bets, choices, and predictions for the game.

The Phillies vs. Astros game is scheduled to begin at 2:10 p.m. ET on Thursday at Houston’s Daikin Park. The major Pennsylvania sportsbooks’ predictions for this interleague game are listed below:

Phillies vs. Astros predictions and best bets

Christopher Sanchez Over 4.5 Strikeouts:

-150 odds at

DraftKings Sportsbook
Under 7 Runs:

-105 odds at

FanDuel Sportsbook
Isaac Paredes 2+ Total Bases:

+160 odds at

bet365 Sportsbook

*Note: To guarantee you get the best odds, check lines closer to game time. Odds are based on the best value our analysts find as of publication.

This season, Christopher Sanchez has made 15 starts. In 11 of those starts, the left-hander has recorded at least five strikeouts. Given that Sanchez has exceeded that amount in eight of his last ten appearances, it would seem wise to take him to record five or more strikeouts.

Two starters with a collective ERA of 2.37 through 30 outings will face off in the third and final game of this series. Hunter Brown of Houston has made all but two starts this season and given up two earned runs or less. The Under 7 runs appeal to us.

Isaac Paredes, a third baseman for Houston, is 4 for 5 and has hit a home run against Sanchez. Paredes leads Houston with 16 home runs, and righties like him are far more effective against Sanchez than lefties.

Philadelphia is +1.5 at all sportsbooks if you want to place a Run Line wager, which is baseball’s equivalent of point spread wagering.

Phillies vs. Astros moneyline odds analysis

The best moneyline betting odds and analysis for the Phillies vs. Astros are provided here:

Why the Astros could win as the favorite

At BetMGM Sportsbook, the best odds are -145.

With an 8-3 record, 1.88 ERA, and 0.92 WHIP, Hunter Brown is one of the most dominant pitchers in the league. Houston has a strong chance of leading into the later innings with Brown on the hill.

Moreover, the Astros feature a number of productive right-handed hitters, including the previously mentioned Paredes, Jeremy Pena, and Jose Altuve. When facing right-handed hitters, Sanchez of Philadelphia is much less dominant.

At BetMGM Sportsbook, you can get the best moneyline odds for the Astros to win.

Why the Phillies could win as the underdog

The best odds at BetRivers Sportsbook are +125.

Philadelphia has only been swept three times in 2025, but it starts Thursday as the moneyline’s underdog. Prior to losing three of their last four games, the Phillies had won eight of their previous nine games.

The Phillies are in dire need of their bats to wake up after being shut out in each of the first two games of this series, and superstar Bryce Harper is still out due to a wrist injury.

Given that Houston has scored three runs or fewer in four of their last five games, the Phillies will need Sanchez to put up a solid showing if they are to win Thursday afternoon.

BetRivers Sportsbook has the greatest moneyline odds for Philadelphia to defeat Houston.